What is the best signal interface for PC ?

I mean.... the best and the easiest to use.
I remember back in the 2000's I used a serial interface, I think it was the printer serial port, 25 pins or similar. I believe I even used a mouse port as well, that versatile those systems were back then.
What I could do with it was ... program in C++ and pascal back then, using some imported dll's specific for communication with this serial port, I think it was port 40 or 25? It had a number is all I remember. And I could link to it any transistor base, back then I was working exclusively with BJT's, to light LED's, drive motors, beep some 8ohm I think they were speakers, drive a VU-meter LED bar I think directly from the port pins, without transistors, and also drive IC's , that was the time I learned about multiplexers and expanding the number of output pins. Also input sensors like LDR and buttons. I Loved that kind of easy and straight forward communication.
Today I dont know c++ or pascal anymore, but I am very good in c# and still use VS2010 because its very cool interface and very user friendly overall.
So I want you, to help me first of all, to find the hardware, the port I suppose or something more than a printer port, something more advanced and having more in/out's. The more the better. I want the best you can find for the moment. Best ideas or best adaptations, why not. As long as it's easy and stable to install and use.
And then, the software drivers and possible problems will appear along the way. I can debug a large majority of problems, I grow up debugging computer problems, so I have a 5'th sense for them. Im more concerned about the hardware part and the integration with my win7 that I still run today and my VisualStudio2010 for my c#. I know I still run old software but they are extremely stable and they don't f me up.
Thank you and I'm really curious what you will find for me.