I've installed them, they are not a like for like with a traditional heating appliance, they work off lower flow temperatures so radiators may need re-sizing. A good alternative in smaller properties provided they are well insulated etc, on a larger property your better off looking at biomass. They need to be well sized for the property, too small and they'll work their knackers off and cost a fortune, too big an they'll tick over costing you a fortune. Good design is key.
Down south they seem to offer good potential as the average winter temp is higher than up north, the colder it gets the harder they work the more they cost.